Let $R$ be a prime ring of characteristic different from $2$ and $3$, $Q_r$ its right Martindale quotient ring and $C$ its the extended centroid. Suppose that $F$ is a non-zero generalized skew derivation of $R$ such that $F([x,y]_k)=[F(x),y]_k+[x,F(y)]_k$ for all $x,y\in R$, with $k>1$ fixed integer. In this paper we will showw that, then $R$ is commutative. $$F([x; y]_k) = [F(x); y]_k + [x; F(y)]_k$$ for all $x, y \in R$, with $k > 1$ fixed integer. Then $R$ is commutative.